CXL vs. Holcomb C3-R Keratoconus Treatments Uncovered

CXL and Holcomb C3-R are two different types of ways to perform crosslinking. Although there have been many controversies among the two procedures, they are significantly different. CXL (epi-off) is an invasive procedure that scrapes the corneal epithelium off, causing a painful recovery. Besides the painful healing process, blurry vision and risks of developing a corneal infection/ulcer(s), scarring and corneal haze are at a 5% rate. The recovery time for CXL can take up to 6 months, however for the first 3 to 6 months the vision fluctuates. The overall complication rate was recently reported as 11%, and the worsening rate is 28.4% in just 12 months of the CXL clinical trials, leaving 26.5 % of CXL patients to suffer with vision loss. As for the Holcomb C3-R, the procedure is “epi-on”, making it non-invasive. Holcomb C3-R has the longest track record of any form of crosslinking in North America. 99.3 % of people have stabilized vision with one treatment, with the retreatment rate being 0.7% (less than 1%). Holcomb C3-R also covers 157% more cornea surface area compared to other techniques. This 10 minute procedure is performed with topical numbing drops. Many patients describe the procedure as being easier than a dentist appointment, which is why most people choose the Holcomb C3-R procedure. For more information on CXL Cross linking and Holcomb C3-R

cxl vs c3r infographic